Endocrine Abstracts

Background: Although SGLT2 inhibitors (SGLT2-i) have revolutionised the management of diabetes, they are associated with an increased risk of developing diabetic ketoacidosis (DKA). However, there remains a paucity of evidence about the risk factors, management, and outcomes of DKA episodes associated with SGLT2-i therapy. Improved understanding of these factors in order to optimise education, minimise risk, and improve outcomes of DKA episodes in individuals receiving SGLT2-i...

Introduction: Simulation via Instant Messaging – Birmingham Advance (SIMBA) is a virtual simulation-based medical training model that improves clinicians’ confidence. However, it has lacked input from patients living with these conditions. Engaging patients and members of the public in the formulation and discussion of cases could guide clinicians to tailor management to meet the concerns and expectations of patients better.Method: A two-day co...

Objective: To explore the differences in various assessments recommended by the International PCOS guidelines during the initial consultation for women with PCOS across Europe.Methods: This retrospective multi-centre study was conducted from June 2023 to January 2024. All women over age 18 who attended their first consultation in a dedicated PCOS clinic from 1st January 2020 to 31st December 2023 in the UK (n=359), Turkey (n=239), Greec...

Objective: To explore whether assessments recommended by the International PCOS guidelines during the initial consultation for PCOS varied by ethnicity.Methods: This retrospective multi-centre study was conducted from June 2023 to January 2024. All women aged >18 who attended their first consultation in a dedicated PCOS clinic from January 2020 to December 2023 in the UK (n=359), Turkey (n=239), Greece (n=92), and Georgia (...

Background: The gonads are the major source of classic androgens during reproductive years. Additionally, the adrenal gland produces precursors for both classic and 11-oxygenated androgen biosynthesis, with androgen activation predominantly occurring in peripheral target tissues of androgen action. We used liquid chromatography-tandem mass spectrometry to profile classic and 11-oxygenated androgens in serum and saliva across the adult age range and assessed diurnal as well as ...

Introduction: National Institute of Health and Care Excellence (NICE) recommends screening for emotional wellbeing as part of consultations for polycystic ovary syndrome (PCOS).Aim: We evaluated several dimensions of emotional wellbeing in people attending PCOS consultation in the UK and India.Methods: All people attending reproductive endocrine clinic for PCOS at three centres: Queen Elizabeth Hospital Birmingham, UK; Apollo Hospi...

Aim: To study differences in various aspects of emotional wellbeing among women with PCOS living in the UK and India.Methods: Women with PCOS were invited to complete an online survey between September and October 2020 in the UK and May and June 2021 in India. The survey included Hospital Anxiety and Depression Scale (HADS; score ≥11 cases of anxiety and depression, respectively), Body Image Concern Inventory (BICI; score ≥72 suggestive of bo...

Background: Simulation via Instant Messaging - Birmingham Advance (SIMBA) is an online simulation learning modality designed to recreate clinical scenarios, allowing participants to increase their confidence in a safe environment without compromising patient safety. The global rating scale (GRS) is a commonly used assessment tool in medical schools to assess participant competence and skills. Following SIMBA sessions, an independent assessor anonymously scores participants&#14...

Objective: This study investigated the association between ethnicity, birthplace and emotional and psychosexual wellbeing in women with Polycystic Ovary Syndrome (PCOS) in the community.Design: International cross-sectional study.Methods: Women with a self-reported PCOS diagnosis by a healthcare professional were invited to complete an online Blue Morpho questionnaire between September-October 2020 (UK) and May-June 2021 (India). F...

Background: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder, with an estimated prevalence of 10-15% worldwide. PCOS can have adverse consequences on the emotional wellbeing of the patient. However, evidence exploring the relationship between PCOS and psychosexual wellbeing, specifically sexual function, and dysmorphic appearance concerns, is largely inconclusive.Aim: A systematic review and meta-analysis were undertaken to assess differ...